DYRK3 Antikörper (N-Term)

Produktnummer ABIN2779364

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-DYRK3 Antikörper (ABIN2779364) detektiert spezifisch DYRK3 in WB und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für DYRK3 Antikörper (N-Term) (ABIN2779364)

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DYRK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-DYRK3 Antikörper

Bindungsspezifität: N-Term

Sequenz: GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS

Homologie: Human: 100%, Mouse: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against DYRK3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DYRK3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 588 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-DYRK3 Antikörper (ABIN2779364)

Wippich, Bodenmiller, Trajkovska, Wanka, Aebersold, Pelkmans: "Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling." in: Cell, Vol. 152, Issue 4, pp. 791-805, (2013) (PubMed).

Details zu DYRK3

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Andere Bezeichnung: DYRK3

Hintergrund: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: DYRK5, RED, REDK, hYAK3-2
Protein Interaction Partner: DYRK3, SORL1, FBXO25, PRNP, NEDD4L,
Protein Size: 588

Molekulargewicht: 66 kDa

Gen-ID: 8444

NCBI Accession: NM_003582, NP_003573

UniProt: O43781

Pathways: Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha