beta Arrestin 1 Antikörper (Middle Region)

Produktnummer ABIN2779340

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch beta Arrestin 1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Rind (Kuh), Pferd und Hund.

Kurzübersicht für beta Arrestin 1 Antikörper (Middle Region) (ABIN2779340)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reaktivität: Human, Rind (Kuh), Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Arrestin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-beta Arrestin 1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: ARRB1 Antibody - middle region

Sequenz: NETPVDTNLI ELDTNDDDIV FEDFARQRLK GMKDDKEEEE DGTGSPQLNN

Homologie: Cow: 90%, Dog: 100%, Horse: 100%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ARRB1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ARRB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30523-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Andere Bezeichnung: ARRB1

Hintergrund:

Background Information: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.

Gene Name: Arrestin, beta 1

Alternative Symbols: ARB1, ARR1

Protein Name: Beta-arrestin-1

Molekulargewicht: 47kDa

Gen-ID: 408

NCBI Accession: NP_004032

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction