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Crk Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Crk in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen und Pferd.
Produktnummer ABIN2779332

Kurzübersicht für Crk Antikörper (C-Term) (ABIN2779332)

Target

Alle Crk (CRK) Antikörper anzeigen
Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Reaktivität

  • 87
  • 22
  • 17
  • 6
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd

Wirt

  • 75
  • 12
Kaninchen

Klonalität

  • 73
  • 14
Polyklonal

Konjugat

  • 44
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Crk Antikörper ist unkonjugiert

Applikation

  • 64
  • 35
  • 27
  • 27
  • 17
  • 12
  • 9
  • 7
  • 7
  • 7
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 28
    • 15
    • 10
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Sequenz

    IPVPYVEKYR PASASVSALI GGNQEGSHPQ PLGGPEPGPY AQPSVNTPLP

    Homologie

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

    Produktmerkmale

    This is a rabbit polyclonal antibody against CRK. It was validated on Western Blot.

    Aufreinigung

    Affinity Purified
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 304 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

    Andere Bezeichnung

    CRK

    Hintergrund

    This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
    Alias Symbols: CRKII, p38
    Protein Interaction Partner: FAM154A, HUWE1, ABL2, ABL1, SPRR2A, MET, CBL, BAG3, LMNA, ERBB3, ERBB2, EGFR, PPFIBP2, ATXN1, PTPN4, MAPK4, DOK1, BCAR1, NANS, FUBP1, SPR, HSPB1, DHX9, SERPINH1, ATIC, PIK3R2, PIK3R1, PIK3CD, PIK3CB, PIK3CA, PIK3C2B, SERPINB6, LYZ, KRT19, KRT17, KRT16, KR
    Protein Size: 304

    Molekulargewicht

    34 kDa

    Gen-ID

    1398

    NCBI Accession

    NM_016823, NP_058431

    UniProt

    P46108

    Pathways

    Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
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