DAZAP1 Antikörper (C-Term)

Produktnummer ABIN2779143

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DAZAP1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Meerschweinchen, Zebrafisch (Danio rerio) und Pferd.

Kurzübersicht für DAZAP1 Antikörper (C-Term) (ABIN2779143)

Target: DAZAP1 (DAZ Associated Protein 1 (DAZAP1))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Zebrafisch (Danio rerio), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DAZAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-DAZAP1 Antikörper

Bindungsspezifität: C-Term

Sequenz: LAFPPPPSQA APDMSKPPTA QPDFPYGQYA GYGQDLSGFG QGFSDPSQQP

Homologie: Dog: 86%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 93%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against DAZAP1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DAZAP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 407 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DAZAP1

Target: DAZAP1 (DAZ Associated Protein 1 (DAZAP1))

Andere Bezeichnung: DAZAP1

Hintergrund: In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. DAZAP1 is a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL.In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.
Protein Interaction Partner: UBC, WWOX, RPA3, RPA2, RPA1, SUZ12, RNF2, EZH2, BMI1, rev, ITCH, RAD52, VCAM1, ITGA4, FN1, BRCA1, CAND1, COPS5, CUL1, CUL2, CUL3, CUL4B, CUL5, NEDD8, ELAVL1, SUMO2, DAZ1, DAZL,
Protein Size: 407

Molekulargewicht: 45 kDa

Gen-ID: 26528

NCBI Accession: NM_018959, NP_061832

UniProt: Q96EP5