PCBP2 Antikörper (Middle Region)

Produktnummer ABIN2778923

Der Kaninchen Polyklonal Anti-PCBP2-Antikörper wurde für WB und IHC validiert. Er ist geeignet, PCBP2 in Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen und Pferd zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für PCBP2 Antikörper (Middle Region) (ABIN2778923)

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PCBP2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PCBP2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PCBP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 366 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PCBP2 Antikörper (ABIN2778923)

Lin, Yang, Liu, Tan, Wu, Hu, Jiang, Bao, Yuan, Qiang, Peng, Han: "Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion." in: Oncotarget, Vol. 7, Issue 15, pp. 19483-98, (2016) (PubMed).

Han, Xin, Zhao, Bao, Lin, Yin, Zhao, Yuan, Qiang, Peng: "RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3." in: The Journal of clinical investigation, Vol. 123, Issue 5, pp. 2103-18, (2013) (PubMed).

Details zu PCBP2

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Andere Bezeichnung: PCBP2

Hintergrund: PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.
Alias Symbols: HNRPE2, hnRNP-E2
Protein Interaction Partner: FUS, HUWE1, UBC, SNRPA, SUMO2, SUMO3, CEP250, MDM2, EED, TARDBP, ADRB2, IGSF8, HMGA1, CD81, HMGA2, WDR83, SLU7, CASK, UBL4A, VCAM1, PCBP2, NOS2, ITGA4, FN1, BRCA1, PRPF40A, SF3B2, NKAP, WDR77, PAXIP1, BARD1, PPIB, EEF1A1, FBXO6, UBD, PCBP1, QKI, CDK2, COP
Protein Size: 366

Molekulargewicht: 40 kDa

Gen-ID: 5094

NCBI Accession: NM_005016, NP_005007

UniProt: Q6IPF4