PCBP2 Antikörper (N-Term)

Produktnummer ABIN2778922

Dieses Anti-PCBP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PCBP2 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Hund und Kaninchen.

Kurzübersicht für PCBP2 Antikörper (N-Term) (ABIN2778922)

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PCBP2 Antikörper

Bindungsspezifität: N-Term

Sequenz: KKGESVKKMR EESGARINIS EGNCPERIIT LAGPTNAIFK AFAMIIDKLE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PCBP2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCBP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 366 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PCBP2

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Andere Bezeichnung: PCBP2

Hintergrund: PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HNRPE2, MGC110998, hnRNP-E2
Protein Interaction Partner: FUS, HUWE1, UBC, SNRPA, SUMO2, SUMO3, CEP250, MDM2, EED, TARDBP, ADRB2, IGSF8, HMGA1, CD81, HMGA2, WDR83, SLU7, CASK, UBL4A, VCAM1, PCBP2, NOS2, ITGA4, FN1, BRCA1, PRPF40A, SF3B2, NKAP, WDR77, PAXIP1, BARD1, PPIB, EEF1A1, FBXO6, UBD, PCBP1, QKI, CDK2, COP
Protein Size: 366

Molekulargewicht: 39 kDa

Gen-ID: 5094

NCBI Accession: NM_005016, NP_005007

UniProt: Q6IPF4