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Aconitase 1 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-Aconitase 1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Aconitase 1 in Proben von Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd und Schwein zu detektieren.
Produktnummer ABIN2778793

Kurzübersicht für Aconitase 1 Antikörper (N-Term) (ABIN2778793)

Target

Alle Aconitase 1 (ACO1) Antikörper anzeigen
Aconitase 1 (ACO1)

Reaktivität

  • 108
  • 53
  • 45
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd, Schwein

Wirt

  • 119
  • 4
  • 1
Kaninchen

Klonalität

  • 119
  • 5
Polyklonal

Konjugat

  • 58
  • 14
  • 8
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Aconitase 1 Antikörper ist unkonjugiert

Applikation

  • 108
  • 39
  • 34
  • 33
  • 26
  • 26
  • 21
  • 16
  • 11
  • 11
  • 7
  • 3
  • 2
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 19
    • 17
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC

    Homologie

    Cow: 100%, Dog: 93%, Guinea Pig: 91%, Horse: 92%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 100%

    Produktmerkmale

    This is a rabbit polyclonal antibody against ACO1. It was validated on Western Blot and immunohistochemistry.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human ACO1
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 889 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    Aconitase 1 (ACO1)

    Andere Bezeichnung

    ACO1

    Hintergrund

    ACO1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
    Alias Symbols: IRP1, ACONS, IREB1, IREBP, IREBP1
    Protein Interaction Partner: UBC, FBXL5, DCPS, STRAP, FUBP1, PSMG1, HIST1H2AB, LGALS1, CTPS1, C12orf57, APP, AKT1,
    Protein Size: 889

    Molekulargewicht

    98 kDa

    Gen-ID

    48

    NCBI Accession

    NM_002197, NP_002188

    UniProt

    P28271

    Pathways

    Transition Metal Ion Homeostasis
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