EIF4G2 Antikörper (N-Term)

Produktnummer ABIN2778774

Produktdetails anti-EIF4G2 Antikörper

Target: EIF4G2 (Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF4G2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PNFDGPAAEG QPGQKQSTTF RRLLISKLQD EFENRTRNVD VYDKRENPLL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against EIF4G2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EIF4G2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 907 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu EIF4G2

Target: EIF4G2 (Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2))

Andere Bezeichnung: EIF4G2 (EIF4G2 Produkte)

Synonyme: AAG1 antikoerper, DAP5 antikoerper, NAT1 antikoerper, P97 antikoerper, NAT1B antikoerper, eif4g2 antikoerper, hm:zeh1307 antikoerper, wu:fa14h01 antikoerper, wu:fb44h01 antikoerper, wu:fb59c06 antikoerper, wu:fc21b05 antikoerper, EIF4G2 antikoerper, AA589388 antikoerper, DAP-5 antikoerper, E130105L11Rik antikoerper, Nat1 antikoerper, Natm1 antikoerper, p97 antikoerper, NAT1A antikoerper, im:7148615 antikoerper, wu:fb81f07 antikoerper, wu:fb82b06 antikoerper, wu:fb98h08 antikoerper, dap5 antikoerper, eif4g2.L antikoerper, nat1 antikoerper, eukaryotic translation initiation factor 4 gamma 2 antikoerper, eukaryotic translation initiation factor 4, gamma 2b antikoerper, eukaryotic translation initiation factor 4, gamma 2 antikoerper, eukaryotic translation initiation factor 4 gamma, 2 antikoerper, eIF4G-related protein NAT1 antikoerper, eukaryotic translation initiation factor 4, gamma 2a antikoerper, eukaryotic translation initiation factor 4 gamma, 2 S homeolog antikoerper, EIF4G2 antikoerper, eif4g2b antikoerper, Eif4g2 antikoerper, nat1 antikoerper, eif4g2a antikoerper, eif4g2.S antikoerper

Hintergrund: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. EIF4G2 shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3, eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, EIF4G2 functions as a general repressor of translation by forming translationally inactive complexes. Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3, eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Alias Symbols: AAG1, DAP5, FLJ41344, NAT1, p97, P97
Protein Interaction Partner: SUMO2, UBC, SKIL, RPA2, ITGA4, FN1, Dlg4, POLDIP3, SLIRP, EIF4G3, RAB7A, EIF4H, EIF4G1, EIF4B, EIF4A1, DCUN1D1, EIF3F, MKNK1, EIF2S2, EIF3A, EIF5, EIF4A2, CASP3, NCBP1, EIF4E, MAGEA6,
Protein Size: 907

Molekulargewicht: 102 kDa

Gen-ID: 1982

NCBI Accession: NM_001418, NP_001409

UniProt: P78344