PRMT2 Antikörper (N-Term)

Produktnummer ABIN183891

Dieser Anti-PRMT2 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von PRMT2 in WB und IHC. Geeignet für Human, Ratte, Maus, Rind (Kuh), Pferd, Schwein, Meerschweinchen, Hund und Kaninchen. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für PRMT2 Antikörper (N-Term) (ABIN183891)

Target: PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Schwein, Meerschweinchen, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRMT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PRMT2 Antikörper

Bindungsspezifität: N-Term

Sequenz: ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 433 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PRMT2 Antikörper (ABIN183891)

Burton, Muller, Tu, Padilla-Longoria, Guccione, Torres-Padilla: "Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo." in: Cell reports, Vol. 5, Issue 3, pp. 687-701, (2013) (PubMed).

Zhong, Cao, Zu, Hong, Yang, Liu, Xiao, Ding, Zhao, Liu, Wen: "Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma." in: The FEBS journal, Vol. 279, Issue 2, pp. 316-35, (2012) (PubMed).

Spellman, Ahmed, Dubach, Gardiner: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).

Zhong, Cao, Hong, Yang, Zu, Xiao, Liu, Wen: "Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer." in: Gene, Vol. 487, Issue 1, pp. 1-9, (2011) (PubMed).

Details zu PRMT2

Target: PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))

Andere Bezeichnung: PRMT2

Hintergrund: The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Alias Symbols: HRMT1L1
Protein Interaction Partner: FIP1L1, SPAG8, RIPK2, BAG6, RB1, HNRNPA1, E2F1, UBC, PSMB3, HHV8GK18_gp81, CPSF7, DMRTB1, HNRNPUL1, PRMT2, THRB, PGR, NCOA6, NCOA1, ESR2, RXRA, PRRC2A, ESR1, PPARG, RARA,
Protein Size: 433

Molekulargewicht: 48 kDa

Gen-ID: 3275

NCBI Accession: NM_001535, NP_001526

UniProt: P55345

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding