PRMT7 Antikörper (C-Term)

Produktnummer ABIN2778660

Der Kaninchen Polyklonal anti-PRMT7 Antikörper wird verwendet zum Nachweis von PRMT7 in Proben von Human, Maus, Ratte, Pferd, Meerschweinchen und Hund. Er wurde validiert für WB.

Kurzübersicht für PRMT7 Antikörper (C-Term) (ABIN2778660)

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Reaktivität: Human, Maus, Ratte, Pferd, Meerschweinchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRMT7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRMT7 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Prmt7 Antibody - C-terminal region

Sequenz: GEINDQDRTD HYAQALRTVL LPGSVCLCVS DGSLLSMLAH HLGAEQVFTV

Homologie: Dog: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against Prmt7. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40192-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PRMT7

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Andere Bezeichnung: Prmt7

Hintergrund:

Background Information: Prmt7 is a arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. It specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. It plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. It may also play a role in embryonic stem cell (ESC) pluripotency. It also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro, the relevance of such results is however unclear in vivo.

Gene Name: Protein arginine N-methyltransferase 7

Alternative Symbols: BC006705, 4933402B05Rik

Protein Name: Protein arginine N-methyltransferase 7

Molekulargewicht: 78kDa

Gen-ID: 214572

NCBI Accession: NP_663379

UniProt: Q922X9

Pathways: Ribonucleoprotein Complex Subunit Organization