RNF34 Antikörper (Middle Region)

Produktnummer ABIN2778633

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RNF34 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd und Meerschweinchen.

Kurzübersicht für RNF34 Antikörper (Middle Region) (ABIN2778633)

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF34 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RNF34 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: RNF34 Antibody - middle region

Sequenz: LVDLVLCHHG LGSEDDMDTS SLNSSRSQTS SFFTRSFFSN YTAPSATMSS

Homologie: Cow: 87%, Dog: 93%, Guinea Pig: 80%, Horse: 93%, Human: 100%, Rabbit: 80%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against RNF34. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RNF34

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40158-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Andere Bezeichnung: RNF34

Hintergrund:

Background Information: RNF34 contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis.The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene Name: Ring finger protein 34, E3 ubiquitin protein ligase

Alternative Symbols: RFI, RIF, RIFF, hRFI, CARP1, CARP-1

Protein Name: E3 ubiquitin-protein ligase RNF34

Molekulargewicht: 42kDa

Gen-ID: 80196

NCBI Accession: NP_079402

UniProt: Q969K3