EYA4 Antikörper (N-Term)

Produktnummer ABIN2778551

Dieses Anti-EYA4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EYA4 in WB. Geeignet für Human, Kaninchen, Meerschweinchen, Maus, Hund und Zebrafisch (Danio rerio).

Kurzübersicht für EYA4 Antikörper (N-Term) (ABIN2778551)

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Reaktivität: Human, Kaninchen, Meerschweinchen, Maus, Hund, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EYA4 Antikörper

Bindungsspezifität: N-Term

Sequenz: MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS

Homologie: Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against Eya4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Eya4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 616 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu EYA4

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Andere Bezeichnung: Eya4

Hintergrund: Eya4 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Eya4 promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. It may be involved in development of the eye.
Alias Symbols: B130023L16Rik
Protein Interaction Partner: Six1, Six2, Eya4,
Protein Size: 616

Molekulargewicht: 67 kDa

Gen-ID: 14051

NCBI Accession: NM_010167, NP_034297

UniProt: Q9Z191

Pathways: Sensory Perception of Sound