TRIM21 Antikörper (N-Term)

Produktnummer ABIN2778305

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TRIM21 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Meerschweinchen, Hund und Kaninchen.

Kurzübersicht für TRIM21 Antikörper (N-Term) (ABIN2778305)

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TRIM21 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: TRIM21 Antibody - N-terminal region

Sequenz: GELRRKQELA EKLEVEIAIK RADWKKTVET QKSRIHAEFV QQKNFLVEEE

Homologie: Dog: 77%, Guinea Pig: 92%, Human: 100%, Mouse: 83%, Rabbit: 85%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against TRIM21. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM21

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34175-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu TRIM21

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Andere Bezeichnung: TRIM21

Hintergrund:

Background Information: TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM21 is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus.This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Tripartite motif containing 21

Alternative Symbols: SSA, RO52, SSA1, RNF81, Ro/SSA

Protein Name: E3 ubiquitin-protein ligase TRIM21

Molekulargewicht: 54kDa

Gen-ID: 6737

NCBI Accession: NP_003132

UniProt: P19474