Claudin 5 Antikörper (C-Term)

Produktnummer ABIN2778047

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Claudin 5 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Schwein, Rind (Kuh), Kaninchen und Meerschweinchen und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für Claudin 5 Antikörper (C-Term) (ABIN2778047)

Target: Claudin 5 (CLDN5)

Reaktivität: Human, Ratte, Maus, Schwein, Rind (Kuh), Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Claudin 5 Antikörper

Bindungsspezifität: C-Term

Sequenz: GWAATALLMV GGCLLCCGAW VCTGRPDLSF PVKYSAPRRP TATGDYDKKN

Homologie: Cow: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CLDN5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 218 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Claudin 5 Antikörper (ABIN2778047)

Yang, Liu, Miao, Yang, Fu, Dou, Cai, Zong, Tan, Chen, Wang: "Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier." in: Oncotarget, Vol. 7, Issue 39, pp. 63839-63855, (2016) (PubMed).

Fontijn, Volger, Fledderus, Reijerkerk, de Vries, Horrevoets: "SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function." in: American journal of physiology. Heart and circulatory physiology, Vol. 294, Issue 2, pp. H891-900, (2008) (PubMed).

Details zu Claudin 5

Target: Claudin 5 (CLDN5)

Andere Bezeichnung: CLDN5

Hintergrund: CLDN5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AWAL, BEC1, CPETRL1, TMVCF
Protein Interaction Partner: UBC, MPDZ, CLDN3, CLDN5, TJP1, CLDN1,
Protein Size: 218

Molekulargewicht: 23 kDa

Gen-ID: 7122

NCBI Accession: NM_003277, NP_003268

UniProt: O00501

Pathways: Hepatitis C