Claudin 19 Antikörper (C-Term)

Produktnummer ABIN2778043

Der Kaninchen Polyklonal anti-Claudin 19 Antikörper (ABIN2778043) detektiert spezifisch Claudin 19 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Schwein, Kaninchen und Pferd.

Kurzübersicht für Claudin 19 Antikörper (C-Term) (ABIN2778043)

Target: Claudin 19 (CLDN19)

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Schwein, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Claudin 19 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CLDN19 Antibody - C-terminal region

Sequenz: AVLGGSFLCC TCPEPERPNS SPQPYRPGPS AAAREPVVKL PASAKGPLGV

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CLDN19. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN19

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33619-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Claudin 19

Target: Claudin 19 (CLDN19)

Andere Bezeichnung: CLDN19

Hintergrund:

Background Information: CLDN19 belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: Claudin 19

Alternative Symbols: HOMG5

Protein Name: Claudin-19

Molekulargewicht: 23kDa

Gen-ID: 149461

NCBI Accession: NP_683763

UniProt: Q8N6F1

Pathways: Cell-Cell Junction Organization, Hepatitis C