Tumor Protein p73 Antikörper (N-Term)

Produktnummer ABIN2777952

Dieses Anti-Tumor Protein p73-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Tumor Protein p73 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio) und Schwein.

Kurzübersicht für Tumor Protein p73 Antikörper (N-Term) (ABIN2777952)

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tumor Protein p73 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Tumor Protein p73 Antikörper

Bindungsspezifität: N-Term

Sequenz: AQSTATSPDG GTTFEHLWSS LEPDSTYFDL PQSSRGNNEV VGGTDSSMDV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Pig: 92%, Rat: 93%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against TP73. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TP73

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 636 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Tumor Protein p73

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Andere Bezeichnung: TP73

Hintergrund: TP73 belongs to the p53 family. It participates in the apoptotic response to DNA damage. When overproduced, it activates transcription from p53-responsive promoters and induces apoptosis. TP53 may be a tumor suppressor protein. This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms, however, the biological validity and the full-length nature of most variants have not been determined.
Alias Symbols: P73
Protein Interaction Partner: FUS, YAP1, WWOX, UBC, TRIM32, SOX2, PFDN5, MYC, EP300, CDK2, CCNE1, CCNB1, CCNA2, CCND1, XPO1, PIN1, AURKA, PRKACA, MAD2L1, HSPA9, CDC20, TP53BP1, RBX1, DDB1, RCHY1, KAT2B, NEDD8, MDM2, IKBKB, DAXX, CHUK, BUB1B, BRCA1, TNK2, AMPH, CREBBP, KAT5, CEP131, MD
Protein Size: 636

Molekulargewicht: 69 kDa

Gen-ID: 7161

NCBI Accession: NM_005427, NP_005418

UniProt: O15350

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus