T-Box 5 Antikörper (N-Term)

Produktnummer ABIN2777915

Der Kaninchen Polyklonal Anti-T-Box 5-Antikörper wurde für WB und IHC validiert. Er ist geeignet, T-Box 5 in Proben von Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Rind (Kuh), Pferd, Zebrafisch (Danio rerio), Ziege und Schaf zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für T-Box 5 Antikörper (N-Term) (ABIN2777915)

Target: T-Box 5 (TBX5)

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Rind (Kuh), Pferd, Zebrafisch (Danio rerio), Ziege, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser T-Box 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-T-Box 5 Antikörper

Bindungsspezifität: N-Term

Sequenz: NSMHKYQPRL HIVKADENNG FGSKNTAFCT HVFPETAFIA VTSYQNHKIT

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TBX5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TBX5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 518 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-T-Box 5 Antikörper (ABIN2777915)

Baban, Pitto, Pulignani, Cresci, Mariani, Gambacciani, Digilio, Pongiglione, Albanese: "Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation." in: American journal of medical genetics. Part A, Vol. 164A, Issue 6, pp. 1419-24, (2014) (PubMed).

Zhang, Huang, Zuo, Chen, Wang: "Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling." in: Aquatic toxicology (Amsterdam, Netherlands), Vol. 142-143, pp. 26-32, (2013) (PubMed).

Lu, Tsai, Choo, Yeh, Tang, Yang, Lee, Lu: "Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos." in: Journal of biomedical science, Vol. 18, pp. 73, (2011) (PubMed).

Details zu T-Box 5

Target: T-Box 5 (TBX5)

Andere Bezeichnung: TBX5

Hintergrund: TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX5 is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in TBX5 have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for TBX5.
Alias Symbols: HOS
Protein Interaction Partner: KDM6A, SMARCA4, KAT5, GATA4, NKX2-5,
Protein Size: 518

Molekulargewicht: 58 kDa

Gen-ID: 6910

NCBI Accession: NM_000192, NP_000183

UniProt: Q99593