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ATXN7 Antikörper (Middle Region)

Dieses Rabbit Polyclonal-Antikörper erkennt spezifisch ATXN7 in WB. Er zeigt eine Reaktivität gegenüber Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Cow, Pig und wurde in 1 Publikation erwähnt.
Produktnummer ABIN2777891

Kurzübersicht für ATXN7 Antikörper (Middle Region) (ABIN2777891)

Target

Alle ATXN7 Antikörper anzeigen
ATXN7 (Ataxin 7 (ATXN7))

Reaktivität

  • 31
  • 28
  • 19
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Kaninchen, Hund, Meerschweinchen, Pferd, Rind (Kuh), Schwein

Wirt

  • 46
  • 1
Kaninchen

Klonalität

  • 46
  • 1
Polyklonal

Konjugat

  • 17
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ATXN7 Antikörper ist unkonjugiert

Applikation

  • 35
  • 20
  • 13
  • 13
  • 5
  • 3
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequenz

    TRSLTCKTHS LTQRRAVQGR RKRFDVLLAE HKNKTREKEL IRHPDSQQPP

    Homologie

    Cow: 92%, Dog: 92%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 92%, Rat: 92%

    Produktmerkmale

    This is a rabbit polyclonal antibody against ATXN7. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human ATXN7
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 892 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Mu, Lin, Chen, Sung, Bai, Jow: "The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates." in: Pediatrics and neonatology, Vol. 49, Issue 6, pp. 230-3, (2009) (PubMed).

  • Target

    ATXN7 (Ataxin 7 (ATXN7))

    Andere Bezeichnung

    ATXN7

    Hintergrund

    ATXN7 is involved in neurodegeneration. ATXN7 acts as component of the STAGA transcription coactivator-HAT complex. ATXN7 mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
    Alias Symbols: ADCAII, OPCA3, SCA7
    Protein Interaction Partner: VCP, USP22, PICK1, TP53BP2, RAD23A, ATXN7L3, ENY2, PIAS1, SUMO1, UBE2I, SUMO2, KAT2A, AGRN, LRSAM1, ADAM33, CEP70, COG6, TRIM54, CEP72, RNF31, PPP1R12C, CRIM1, TXNDC11, EFEMP2, UBQLN2, CARD10, NOC2L, NUP62, MPRIP, SPRY1, GPRASP1, PNMA1, RABEP1, KALRN, LTB
    Protein Size: 892

    Molekulargewicht

    95 kDa

    Gen-ID

    6314

    NCBI Accession

    NM_000333, NP_000324

    UniProt

    O15265
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