ING3 Antikörper (Middle Region)

Produktnummer ABIN2777878

Der Kaninchen Polyklonal Anti-ING3-Antikörper wurde für WB und IHC validiert. Er ist geeignet, ING3 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio) und Saccharomyces cerevisiae zu detektieren.

Kurzübersicht für ING3 Antikörper (Middle Region) (ABIN2777878)

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ING3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ING3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: LSSGTGAGAI TMAAAQAVQA TAQMKEGRRT SSLKASYEAF KNNDFQLGKE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 75%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against ING3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ING3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 418 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ING3

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Andere Bezeichnung: ING3

Hintergrund: ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Alias Symbols: Eaf4, FLJ20089, ING2, p47ING3, MEAF4
Protein Interaction Partner: USHBP1, TRIM54, TEX11, FBXO25, APP, H2AFZ, ELAVL1, NR1H3, NR1H2, DMAP1, MORF4L1, KAT5, RBX1, RUVBL1, CUL1, TRRAP, UBC, SKP2, ACTL6A, EPC1, HHT2, HHT1, MEAF6, EPC2, BRD8, RUVBL2, YEATS4,
Protein Size: 418

Molekulargewicht: 47 kDa

Gen-ID: 54556

NCBI Accession: NM_019071, NP_061944

UniProt: Q9NXR8