BCL11B Antikörper (Middle Region)

Produktnummer ABIN2777845

Der Kaninchen Polyklonal Anti-BCL11B-Antikörper wurde für WB und IHC validiert. Er ist geeignet, BCL11B in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen und Pferd zu detektieren.

Kurzübersicht für BCL11B Antikörper (Middle Region) (ABIN2777845)

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL11B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-BCL11B Antikörper

Bindungsspezifität: Middle Region

Sequenz: QASKLKRHMK THMHKAGSLA GRSDDGLSAA SSPEPGTSEL AGEGLKAADG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against BCL11B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BCL11B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 823 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BCL11B

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Andere Bezeichnung: BCL11B

Hintergrund: BCL11B is the tumor-suppressor protein involved in T-cell lymphomas. BCL11B may function on the P53-signaling pathway. BCL11B may be a key regulator of both differentiation and survival during thymocyte development. BCL11B repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Alias Symbols: CTIP-2, CTIP2, RIT1, hRIT1-alpha, ZNF856B
Protein Interaction Partner: HDAC6, HDAC2, HDAC1, NOTCH1, UBC, HDAC3, SUV39H1, tat, CBX5, NR2F1, SP1, MBD3, MTA2, MTA1, RBBP7, RBBP4, CHD4, NR2F2,
Protein Size: 823

Molekulargewicht: 88 kDa

Gen-ID: 64919

NCBI Accession: NM_022898, NP_075049