APP Antikörper (Amyloid beta (A4) Precursor Protein) (Middle Region)

Details for Product anti-APP Antibody No. ABIN2777739, Anbieter: Anmelden zum Anzeigen
Antigen
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • amyloid beta precursor protein
  • amyloid beta (A4) precursor protein
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein a
  • amyloid beta precursor protein L homeolog
  • APP
  • app
  • Appl
  • App
  • appa
  • app.L
Epitop
Middle Region
106
102
70
39
37
32
31
19
17
15
15
14
14
13
12
10
9
7
7
7
7
6
6
5
5
5
5
5
5
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
931
383
361
39
27
21
18
18
14
13
11
10
7
7
4
4
4
3
2
2
1
Wirt
Kaninchen
646
261
51
7
2
Klonalität
Polyklonal
Konjugat
Dieser APP Antikörper ist unkonjugiert
51
43
41
17
16
14
14
14
13
13
13
13
13
13
13
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
668
405
292
159
159
122
82
57
40
36
17
15
15
10
8
3
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human APP
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN973340.
Sequenz RMNQSLSLLY NVPAVAEEIQ DEVDELLQKE QNYSDDVLAN MISEPRISYG
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against APP. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung APP (APP Antibody Abstract)
Hintergrund APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II
Protein Size: 770
Molekulargewicht 85 kDa
Gen-ID 351
NCBI Accession NM_000484, NP_000475
UniProt P05067
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 770 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Amyloid beta (A4) Precursor Protein (APP) (Middle Region) antibody (ABIN2777739) Sample Type : Mouse hippo campus Primary Antibody Dilution : 1:100 Secondary Antib...
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (Middle Region) antibody (ABIN2777739) WB Suggested Anti-APP Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:2500 Positive Co...
Allgemeine Veröffentlichungen Locascio, Fukumoto, Yap, Bottiglieri, Growdon, Hyman, Irizarry: "Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease." in: Archives of neurology, Vol. 65, Issue 6, pp. 776-85, 2008 (PubMed).

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