PCK1 Antikörper (N-Term)

Produktnummer ABIN2777601

Dieses Anti-PCK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PCK1 in WB. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Pferd und Meerschweinchen.

Kurzübersicht für PCK1 Antikörper (N-Term) (ABIN2777601)

Target: PCK1 (phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PCK1 Antikörper

Bindungsspezifität: N-Term

Sequenz: PPQLQNGLNL SAKVVQGSLD SLPQAVREFL ENNAELCQPD HIHICDGSEE

Homologie: Cow: 100%, Dog: 85%, Guinea Pig: 92%, Horse: 85%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PCK1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCK1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 622 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PCK1

Target: PCK1 (phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1))

Andere Bezeichnung: PCK1

Hintergrund: PCK1 is a main control point for the regulation of gluconeogenesis. PCK1, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of PCK1 can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC22652, PEPCK-C, PEPCK1, PEPCKC
Protein Interaction Partner: UBC, FBXO25, C1R, APP, CUL5, BAG6, TCP1, TCEB1, SKP1, RPS15A, RPS6, RPS3A, RPS3, RPLP0, RPL4, PSMD12, PSMD2, PSMC5, PSMC4, PSMC2, PSMC1, PSMB7, PSMB4, PSMB1, PSMA5, PSMA2, PCK1, LDHA, HSPD1, HSPA1L, DNAJA1, HLA-C, HLA-B, GNAS, GNAI1, GNA12, FASN, EP300, T
Protein Size: 622

Molekulargewicht: 69 kDa

Gen-ID: 5105

NCBI Accession: NM_002591, NP_002582

UniProt: P35558

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis