Paired Box 3 Antikörper (C-Term)

Produktnummer ABIN2777556

Dieses Anti-Paired Box 3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Paired Box 3 in WB und IHC. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen und Zebrafisch (Danio rerio).

Kurzübersicht für Paired Box 3 Antikörper (C-Term) (ABIN2777556)

Target: Paired Box 3 (PAX3)

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Paired Box 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Paired Box 3 Antikörper

Bindungsspezifität: C-Term

Sequenz: GGVPHQPQTD YALSPLTGGL EPTTTVSASC SQRLDHMKSL DSLPTSQSYC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PAX3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PAX3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 479 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Paired Box 3

Target: Paired Box 3 (PAX3)

Andere Bezeichnung: PAX3

Hintergrund: PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma.This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
Alias Symbols: WS1, WS3, CDHS, HUP2
Protein Interaction Partner: PCTP, UBC, TAF1, POU3F2, HDAC1, TRIM28, HDAC10, SOX8, WWTR1, PAX3, DAXX, CIB1, SOX10, MEOX2, MEOX1, MITF, MSX1, Rad23b, PSMD4, TBP, IPO13, CNR1,
Protein Size: 479

Molekulargewicht: 53 kDa

Gen-ID: 5077

NCBI Accession: NM_181457, NP_852122

UniProt: P23760

Pathways: Sensory Perception of Sound, Tube Formation