NOTCH2 Antikörper (Middle Region)

Produktnummer ABIN2777549

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-NOTCH2 Antikörper wird verwendet zum Nachweis von NOTCH2 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Meerschweinchen und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für NOTCH2 Antikörper (Middle Region) (ABIN2777549)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTCH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NOTCH2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: NOTCH2 Antibody - middle region

Sequenz: FPASVGKYPT PPSQHSYASS NAAERTPSHS GHLQGEHPYL TPSPESPDQW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against NOTCH2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NOTCH2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32723-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NOTCH2 Antikörper (ABIN2777549)

Tilley, Harvey, Heguy, Hackett, Wang, OConnor, Crystal: "Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 179, Issue 6, pp. 457-66, (2009) (PubMed).

Details zu NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Andere Bezeichnung: NOTCH2

Hintergrund:

Background Information: NOTCH2 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. NOTCH2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Notch 2

Alternative Symbols: hN2, AGS2, HJCYS

Protein Name: Neurogenic locus notch homolog protein 2

Molekulargewicht: 85kDa

Gen-ID: 4853

NCBI Accession: NP_077719

UniProt: Q04721

Pathways: Notch Signalweg, Stem Cell Maintenance