DREAM Antikörper (N-Term)

Produktnummer ABIN2777506

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-DREAM Antikörper wird verwendet zum Nachweis von DREAM in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio) und Schwein. Er wurde validiert für WB und IHC.

Kurzübersicht für DREAM Antikörper (N-Term) (ABIN2777506)

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DREAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-DREAM Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CSEN Antibody - N-terminal region

Sequenz: STVRHQPEGL DQLQAQTKFT KKELQSLYRG FKNECPTGLV DEDTFKLIYA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against CSEN. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CSEN

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31932-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-DREAM Antikörper (ABIN2777506)

Fernandes, Ribeiro, Martínez, Orensanz, Barahona, Martínez-Sáenz, Recio, Benedito, Bustamante, Carballido, García-Sacristán, Prieto, Hernández: "Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck." in: The Journal of urology, Vol. 189, Issue 4, pp. 1567-73, (2013) (PubMed).

Details zu DREAM

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Andere Bezeichnung: CSEN

Hintergrund:

Background Information: CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The protein encoded by this gene is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease.

Gene Name: Kv channel interacting protein 3, calsenilin

Alternative Symbols: CSEN, DREAM, KCHIP3

Protein Name: Calsenilin

Molekulargewicht: 29kDa

Gen-ID: 30818

NCBI Accession: NP_038462

UniProt: Q9Y2W7