GATA2 Antikörper (N-Term)

Produktnummer ABIN2777458

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GATA2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen und wurde in 6+ Publikationen erwähnt.

Kurzübersicht für GATA2 Antikörper (N-Term) (ABIN2777458)

Target: GATA2 (GATA Binding Protein 2 (GATA2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GATA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GATA2 Antikörper

Bindungsspezifität: N-Term

Sequenz: PYYANPAHAR ARVSYSPAHA RLTGGQMCRP HLLHSPGLPW LDGGKAALSA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GATA2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GATA2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 480 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-GATA2 Antikörper (ABIN2777458)

Wang, Zhu, Guo, Dong, Liu, Yin, Zhang, Li, Liu, Ma, Song, He, Wang, Wang, Zhang, Li, Yu: "A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis." in: Nucleic acids research, Vol. 42, Issue 1, pp. 442-57, (2013) (PubMed).

Fujiwara, Yokoyama, Okitsu, Kamata, Fukuhara, Onishi, Fujimaki, Takahashi, Ishizawa, Bresnick, Harigae: "Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells." in: PLoS ONE, Vol. 7, Issue 9, pp. e40959, (2012) (PubMed).

Jack, Crossley: "GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis." in: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32405-14, (2010) (PubMed).

Huang, Niu, Liu, Wang, Sturgis, Wei: "The functional IGFBP7 promoter -418G>A polymorphism and risk of head and neck cancer." in: Mutation research, Vol. 702, Issue 1, pp. 32-9, (2010) (PubMed).

Mammoto, Connor, Mammoto, Yung, Huh, Aderman, Mostoslavsky, Smith, Ingber: "A mechanosensitive transcriptional mechanism that controls angiogenesis." in: Nature, Vol. 457, Issue 7233, pp. 1103-8, (2009) (PubMed).

Tsuzuki, Kitajima, Nakano, Glasow, Zelent, Enver: "Cross talk between retinoic acid signaling and transcription factor GATA-2." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6824-36, (2004) (PubMed).

Details zu GATA2

Target: GATA2 (GATA Binding Protein 2 (GATA2))

Andere Bezeichnung: GATA2

Hintergrund: The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells.
Alias Symbols: DCML, NFE1B, MONOMAC
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-9, KRT40, PRR20A, ADAMTSL4, TRAF1, PSMA3, MDFI, GOLGA2, FHL3, TRIM23, AKT1, BMI1, SPI1, SMAD4, ELAVL1, KAT2A, EP300, MED1, POU1F1, POU2AF1, ZBTB32, ZFPM1, ZBTB16, HDAC5, HDAC3, HHEX, RARA, RXRA, MAPK1, JUN, CEBPA, STAT3, PML,
Protein Size: 480

Molekulargewicht: 50 kDa

Gen-ID: 2624

NCBI Accession: NM_032638, NP_116027

UniProt: P23769

Pathways: Stem Cell Maintenance