SOX2 Antikörper (N-Term)

Produktnummer ABIN2777428

Der Kaninchen Polyklonal Anti-SOX2-Antikörper wurde für WB und IHC validiert. Er ist geeignet, SOX2 in Proben von Human, Maus, Ratte, Ziege, Rind (Kuh), Schwein, Schaf, Zebrafisch (Danio rerio), Pferd, Kaninchen und Hund zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für SOX2 Antikörper (N-Term) (ABIN2777428)

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Reaktivität: Human, Maus, Ratte, Ziege, Rind (Kuh), Schwein, Schaf, Zebrafisch (Danio rerio), Pferd, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SOX2 Antikörper

Bindungsspezifität: N-Term

Sequenz: MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against SOX2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SOX2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 317 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SOX2 Antikörper (ABIN2777428)

Lenz, Konecna, Tichy, Machacova, Fiala, Hurnik, Kyllar: "Unique expression patterns of the embryonal stem cell marker SOX2 and hormone receptors suggest the existence of a subpopulation of epithelial stem/progenitor cells in porcine and bovine endometrium." in: Veterinary medicine and science, (2022) (PubMed).

Perry, Thomas, Henry: "Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells." in: Developmental biology, Vol. 374, Issue 2, pp. 281-94, (2013) (PubMed).

Details zu SOX2

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Andere Bezeichnung: SOX2

Hintergrund: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ANOP3, MCOPS3, MGC2413
Protein Interaction Partner: SUMO1, DMAP1, TBX2, SETD7, FAM21A, FZR1, MMS19, MRPS35, ZNF462, LSM2, CCAR2, MIER1, ZDBF2, CHD8, EP400, TSHZ3, RANBP10, ZNF687, XPO5, INTS2, MTA3, CORO1B, CASC5, MRPS22, KCMF1, MEPCE, TRERF1, INTS9, PARVA, SCYL2, CHD7, ZCCHC8, SOX6, BRIX1, SAMD4B, GID8, C
Protein Size: 317

Molekulargewicht: 34 kDa

Gen-ID: 6657

NCBI Accession: NM_003106, NP_003097

UniProt: P48431

Pathways: Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis