DDIT3 Antikörper (N-Term)

Produktnummer ABIN2777369

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DDIT3 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Schaf, Hund, Meerschweinchen, Pferd, Ziege und Kaninchen.

Kurzübersicht für DDIT3 Antikörper (N-Term) (ABIN2777369)

Target: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schaf, Hund, Meerschweinchen, Pferd, Ziege, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDIT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-DDIT3 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: DDIT3 Antibody - N-terminal region

Sequenz: SLPFSFGTLS SWELEAWYED LQEVLSSDEN GGTYVSPPGN EEEESKIFTT

Homologie: Cow: 86%, Dog: 86%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 92%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against DDIT3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human DDIT3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31591-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu DDIT3

Target: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Andere Bezeichnung: DDIT3

Hintergrund:

Background Information: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Gene Name: DNA-damage-inducible transcript 3

Alternative Symbols: CHOP, CEBPZ, CHOP10, CHOP-10, GADD153, AltDDIT3, C/EBPzeta

Protein Name: DNA damage-inducible transcript 3 protein Ensembl ENSP00000447803 Ensembl ENSP00000448665

Molekulargewicht: 21kDa

Gen-ID: 1649

NCBI Accession: NP_001181985

UniProt: F8VS99

Pathways: Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis