POU1F1 Antikörper (C-Term)

Produktnummer ABIN182359

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch POU1F1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Ziege, Pferd, Kaninchen, Schaf, Meerschweinchen und Zebrafisch (Danio rerio) und wurde in 1 Publikation erwähnt.

Kurzübersicht für POU1F1 Antikörper (C-Term) (ABIN182359)

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Ziege, Pferd, Kaninchen, Schaf, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POU1F1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-POU1F1 Antikörper

Bindungsspezifität: C-Term

Sequenz: QEIMRMAEEL NLEKEVVRVW FCNRRQREKR VKTSLNQSLF SISKEHLECR

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against POU1F1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human POU1F1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 291 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-POU1F1 Antikörper (ABIN182359)

Tennant, Gottlieb: "HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression." in: Journal of molecular medicine (Berlin, Germany), Vol. 88, Issue 8, pp. 839-49, (2010) (PubMed).

Details zu POU1F1

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Andere Bezeichnung: POU1F1

Hintergrund: PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
Alias Symbols: PIT1, CPHD1, GHF-1, Pit-1, POU1F1a
Protein Interaction Partner: CEBPD, NCOR1, CREBBP, MED1, GATA2, NR1I3, NR1I2, PITX1, JUN, ETS1, NR3C1, VDR, PPARG, PPARA,
Protein Size: 291

Molekulargewicht: 33 kDa

Gen-ID: 5449

NCBI Accession: NM_000306, NP_000297

UniProt: P28069

Pathways: Regulation of Carbohydrate Metabolic Process