NFIL3 Antikörper (Middle Region)

Produktnummer ABIN2777219

Produktdetails anti-NFIL3 Antikörper

Target: NFIL3 (Nuclear Factor, Interleukin 3 Regulated (NFIL3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schaf, Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFIL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GYSHSPPLLQ VNRSSSNSPR TSETDDGVVG KSSDGEDEQQ VPKGPIHSPV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against NFIL3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NFIL3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 462 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NFIL3

Target: NFIL3 (Nuclear Factor, Interleukin 3 Regulated (NFIL3))

Andere Bezeichnung: NFIL3 (NFIL3 Produkte)

Hintergrund: NFIL3 is a basic leucine zipper (bZIP) transcription factor that represses or activates transcription in non-osteoblastic cells. NFIL3 play a role in attenuation of PTH target gene transcription in osteoblasts. NFIL3 repression domain interacts specifically with the TBP binding repressor protein Dr1.Glucocorticoid-mediated upregulation of the bZIP transcriptional repressor gene, NFIL3, is dependent on [Ca2+]i levels, and correlates with Glucocorticoid-evoked apoptosis of Glucocorticoid-sensitive CEM-C7-14 cells. NFIL3 is involved in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E2A-HLF leads to childhood B lineage leukemia.
Alias Symbols: E4BP4, IL3BP1, NF-IL3A, NFIL3A
Protein Interaction Partner: AMOTL2, TRAF2, MAFF, BATF, NFIL3, MAFG, DDIT3, CBX8, SUMO2, UBC, CREB3, DR1,
Protein Size: 462

Molekulargewicht: 51 kDa

Gen-ID: 4783

NCBI Accession: NM_005384, NP_005375

UniProt: Q16649