TNNT1 Antikörper (Middle Region)

Produktnummer ABIN2777153

Der Kaninchen Polyklonal anti-TNNT1 Antikörper wird verwendet zum Nachweis von TNNT1 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für TNNT1 Antikörper (Middle Region) (ABIN2777153)

Target: TNNT1 (Slow Skeletal Troponin T (TNNT1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNNT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TNNT1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: TNNT1 Antibody - middle region

Sequenz: WIHQLESEKF DLMAKLKQQK YEINVLYNRI SHAQKFRKGA GKGRVGGRWK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against TNNT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TNNT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42120-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu TNNT1

Target: TNNT1 (Slow Skeletal Troponin T (TNNT1))

Andere Bezeichnung: TNNT1

Hintergrund:

Background Information: TNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: Troponin T type 1 (skeletal, slow)

Alternative Symbols: ANM, TNT, NEM5, STNT, TNTS

Protein Name: Troponin T, slow skeletal muscle

Molekulargewicht: 33kDa

Gen-ID: 7138

NCBI Accession: NP_003274

UniProt: P13805