PPL Antikörper (Middle Region)
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- Target Alle PPL Antikörper anzeigen
- PPL (Periplakin (PPL))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PPL Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- EKSRAQEKVT EKEVVKLQND PQLEAEYQQL QEDHQRQDQL REKQEEELSF
- Homologie
- Human: 100%, Pig: 82%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PPL. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PPL
- Top Product
- Discover our top product PPL Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1756 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PPL (Periplakin (PPL))
- Andere Bezeichnung
- PPL (PPL Produkte)
- Synonyme
- cb180 antikoerper, sb:cb180 antikoerper, im:7140067 antikoerper, im:7149519 antikoerper, AW553870 antikoerper, periplakin antikoerper, periplakin L homeolog antikoerper, PPL antikoerper, ppl antikoerper, ppl.L antikoerper, Ppl antikoerper
- Hintergrund
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PPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: KIAA0568, MGC134872
Protein Interaction Partner: CEP57L1, ZSCAN1, RAB3IP, TSC22D4, RALBP1, AHCYL1, VIM, TRAF2, TRIM27, ALAS1, AKT1, SKIL, UBC, USP7, CUL1, ITSN1, Cdk1, KAZN, PPHLN1, EVPL, CASP6, OPRM1, COL17A1, KRT8, EZR,
Protein Size: 1756 - Molekulargewicht
- 205 kDa
- Gen-ID
- 5493
- NCBI Accession
- NM_002705, NP_002696
- UniProt
- O60437
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