Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

F13B Antikörper (Middle Region)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch F13B in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd und Kaninchen.
Produktnummer ABIN2777104

Kurzübersicht für F13B Antikörper (Middle Region) (ABIN2777104)

Target

Alle F13B Antikörper anzeigen
F13B (Coagulation Factor 13, B Polypeptide (F13B))

Reaktivität

Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen

Wirt

  • 27
  • 2
Kaninchen

Klonalität

  • 27
  • 2
Polyklonal

Konjugat

  • 21
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser F13B Antikörper ist unkonjugiert

Applikation

  • 25
  • 16
  • 10
  • 5
  • 5
  • 3
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequenz

    LRLIENGYFH PVKQTYEEGD VVQFFCHENY YLSGSDLIQC YNFGWYPESP

    Homologie

    Cow: 100%, Dog: 86%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

    Produktmerkmale

    This is a rabbit polyclonal antibody against F13B. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human F13B
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 661 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    F13B (Coagulation Factor 13, B Polypeptide (F13B))

    Andere Bezeichnung

    F13B

    Hintergrund

    F13B contains 10 Sushi (CCP/SCR) domains. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: FXIIIB
    Protein Interaction Partner: FGG, F13A1,
    Protein Size: 661

    Molekulargewicht

    73 kDa

    Gen-ID

    2165

    NCBI Accession

    NM_001994, NP_001985

    UniProt

    P05160
Sie sind hier:
Chat with us!