FGA Antikörper (Middle Region)

Produktnummer ABIN2776978

Produktdetails anti-FGA Antikörper

Target: FGA (Fibrinogen alpha Chain (FGA))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SSSYSKQFTS STSYNRGDST FESKSYKMAD EAGSEADHEG THSTKRGHAK

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against FGA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FGA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 644 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FGA Antikörper (ABIN2776978)

Matsumoto, Matsuura, Aoki, Maehashi, Iwamoto, Ohkawa, Yoshida, Yanaga, Takada: "An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 45, Issue 3, pp. 315-25, (2016) (PubMed).

Prieto-García, Zheng, Adachi, Xing, Lane, Chung, Anderson, Hansbro, Castells, Stevens: "Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen." in: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 7834-44, (2012) (PubMed).

Details zu FGA

Target: FGA (Fibrinogen alpha Chain (FGA))

Andere Bezeichnung: FGA (FGA Produkte)

Synonyme: Fib2 antikoerper, ENSMUSG00000059807 antikoerper, Fib antikoerper, Ac1873 antikoerper, Fba5e antikoerper, fibrinogen alpha chain antikoerper, FGA antikoerper, Fga antikoerper, LOC698244 antikoerper

Hintergrund: FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
Alias Symbols: Fib2, MGC119422, MGC119423, MGC119425
Protein Interaction Partner: ASB7, ASB6, FN1, APOA1, ALB, UBC, SUMO2, MIS12, KHDRBS2, ITGA2B, SERPINA5, CDH5, SERPINF2, THBS1, F2, ITGB3, PLAT, HRG, PRRC2A, FGG, FGB, FGA, F13A1, NID1,
Protein Size: 644

Molekulargewicht: 66 kDa

Gen-ID: 2243

NCBI Accession: NM_021871, NP_068657

UniProt: Q4QQH7