Keratin 10 Antikörper (N-Term)

Produktnummer ABIN2776960

Produktdetails anti-Keratin 10 Antikörper

Target: Keratin 10 (KRT10)

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Keratin 10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EKVTMQNLND RLASYLDKVR ALEESNYELE GKIKEWYEKH GNSHQGEPRD

Homologie: Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KRT10. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KRT10

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 584 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Keratin 10 Antikörper (ABIN2776960)

Tsubota, Akiyama, Kanitakis, Sakai, Nomura, Claudy, Shimizu: "Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation." in: The Journal of investigative dermatology, Vol. 128, Issue 7, pp. 1648-52, (2008) (PubMed).

Details zu Keratin 10

Target: Keratin 10 (KRT10)

Andere Bezeichnung: KRT10 (KRT10 Produkte)

Hintergrund: KRT10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in the gene encoding KRT10 are associated with epidermolytic hyperkeratosis. This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CK10, K10, KPP, BIE, EHK, BCIE
Protein Interaction Partner: UBC, Fbxl16, ADRB2, PAN2, Nphp4, Iqcb1, Cep290, Nphp1, Invs, VCAM1, SRC, ITGA4, FN1, ALB, MAGOH, TRAF3IP1, EIF4A3, AHNAK2, KRT2, KRT1, ELAVL1, UBASH3B, SHC1, PIK3R2, INPPL1, GRB2, EPS15, CRK, AP2M1, CBL, NEDD8, CAND1, DCUN1D1, COPS5, COPS6, CUL1, CUL2, CU
Protein Size: 584

Molekulargewicht: 59 kDa

Gen-ID: 3858

NCBI Accession: NM_000421, NP_000412

UniProt: P13645