Amylin/DAP Antikörper (N-Term)

Produktnummer ABIN2776959

Produktdetails anti-Amylin/DAP Antikörper

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Bindungsspezifität: N-Term

Reaktivität: Human, Kaninchen, Hund, Rind (Kuh), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Amylin/DAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV

Homologie: Cow: 82%, Dog: 86%, Horse: 93%, Human: 100%, Rabbit: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against IAPP. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human IAPP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 89 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Amylin/DAP

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Andere Bezeichnung: IAPP (IAPP Produkte)

Synonyme: DAP antikoerper, IAP antikoerper, LOC100230121 antikoerper, Amylin antikoerper, islet amyloid polypeptide antikoerper, IAPP antikoerper, Iapp antikoerper

Hintergrund: Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
Alias Symbols: AMYLIN, DAP, IAP
Protein Interaction Partner: COL25A1, RAMP2, RAMP1, PDX1, PCSK2, PCSK1,
Protein Size: 89

Molekulargewicht: 4 kDa

Gen-ID: 3375

NCBI Accession: NM_000415, NP_000406

UniProt: P10997

Pathways: Hormone Activity, Feeding Behaviour