PDZK1 Antikörper (N-Term)

Produktnummer ABIN2776855

Dieses Anti-PDZK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PDZK1 in WB. Geeignet für Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Rind (Kuh) und Kaninchen.

Kurzübersicht für PDZK1 Antikörper (N-Term) (ABIN2776855)

Target: PDZK1 (PDZ Domain Containing 1 (PDZK1))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Rind (Kuh), Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDZK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDZK1 Antikörper

Bindungsspezifität: N-Term

Sequenz: NSVTLLVLDG DSYEKAVKTR VDLKELGQSQ KEQGLSDNIL SPVMNGGVQT

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PDZK1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PDZK1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 519 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PDZK1

Target: PDZK1 (PDZ Domain Containing 1 (PDZK1))

Andere Bezeichnung: PDZK1

Hintergrund: PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. PDZK1 may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. It may function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. PDZK1 may be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Alias Symbols: CAP70, CLAMP, NHERF3, PDZD1, NHERF-3
Protein Interaction Partner: AKT1, CDC37, Ptgir, ABCC4, CFTR, APP, Klhl17, Syngap1, Dlg4, SLC26A6, SLC22A4, SLCO1A2, SLC15A2, PDZK1IP1, SLC22A11, SLC22A12, AKAP10, SLC22A5, ABCC2, SCARB1, CLCN3, PEX5, ABCA1, SSTR5, SLC17A1, SLC9A3, GFAP, SLC34A3, FARP2, SLK, SLC9A3R1, SLC9A3R2, UBE2I
Protein Size: 519

Molekulargewicht: 57 kDa

Gen-ID: 5174

NCBI Accession: NM_002614, NP_002605

UniProt: Q5T2W1