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ACTN2 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ACTN2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen und Zebrafisch (Danio rerio).
Produktnummer ABIN2776830

Kurzübersicht für ACTN2 Antikörper (C-Term) (ABIN2776830)

Target

Alle ACTN2 Antikörper anzeigen
ACTN2 (Actinin, alpha 2 (ACTN2))

Reaktivität

  • 110
  • 64
  • 38
  • 7
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt

  • 80
  • 62
Kaninchen

Klonalität

  • 75
  • 67
Polyklonal

Konjugat

  • 61
  • 12
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ACTN2 Antikörper ist unkonjugiert

Applikation

  • 113
  • 82
  • 50
  • 19
  • 14
  • 13
  • 13
  • 13
  • 11
  • 11
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 57
    • 15
    • 9
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Sequenz

    VIASFRILAS DKPYILAEEL RRELPPDQAQ YCIKRMPAYS GPGSVPGALD

    Homologie

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

    Produktmerkmale

    This is a rabbit polyclonal antibody against ACTN2. It was validated on Western Blot and immunohistochemistry.

    Aufreinigung

    Protein A purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the C terminal region of human ACTN2
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 894 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    ACTN2 (Actinin, alpha 2 (ACTN2))

    Andere Bezeichnung

    ACTN2

    Hintergrund

    The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Transcript variants resulting from the use of multiple poly_A sites have been observed.
    Alias Symbols: CMD1AA
    Protein Interaction Partner: ACTN2, FAM154A, BRMS1L, MICALL2, MYOZ2, PDLIM3, SP100, SNAI1, MOS, RTP5, SYNPO2, SUMO1, IGSF8, ERBB2IP, CAPN1, ZNF446, RPL35, UBC, NOS3, ACTN1, ACTN4, FBXL22, COIL, SUMO3, ATXN2, KCNA5, LDB3, KCNN2, PSMA3, ITGB3BP, SNW1, MED14, NR1I2, KAT2B, NRIP1, ATXN7,
    Protein Size: 894

    Molekulargewicht

    98 kDa

    Gen-ID

    88

    NCBI Accession

    NM_001103, NP_001094

    UniProt

    P35609

    Pathways

    Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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