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ACTN2 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ACTN2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen und wurde in 1 Publikation erwähnt.
Produktnummer ABIN2776829

Kurzübersicht für ACTN2 Antikörper (N-Term) (ABIN2776829)

Target

Alle ACTN2 Antikörper anzeigen
ACTN2 (Actinin, alpha 2 (ACTN2))

Reaktivität

  • 110
  • 64
  • 38
  • 7
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt

  • 80
  • 62
Kaninchen

Klonalität

  • 75
  • 67
Polyklonal

Konjugat

  • 61
  • 12
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ACTN2 Antikörper ist unkonjugiert

Applikation

  • 113
  • 82
  • 50
  • 19
  • 14
  • 13
  • 13
  • 13
  • 11
  • 11
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 57
    • 15
    • 9
    • 9
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    NQIEPGVQYN YVYDEDEYMI QEEEWDRDLL LDPAWEKQQR KTFTAWCNSH

    Homologie

    Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

    Produktmerkmale

    This is a rabbit polyclonal antibody against ACTN2. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human ACTN2
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 894 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Yan, Wang, Sharova, Sharov, Ling, Piao, Aiba, Matoba, Wang, Ko: "BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 5, pp. 1155-65, (2008) (PubMed).

  • Target

    ACTN2 (Actinin, alpha 2 (ACTN2))

    Andere Bezeichnung

    ACTN2

    Hintergrund

    The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-39 DC378038.1 17-55 40-2961 BC051770.1 1-2922 2962-3458 CB153006.1 65-561 3459-3637 AL359185.25 28531-28709 3638-4210 M86406.1 3609-4181 4211-4528 AL359185.25 29283-29600
    Alias Symbols: CMD1AA
    Protein Interaction Partner: ACTN2, FAM154A, BRMS1L, MICALL2, MYOZ2, PDLIM3, SP100, SNAI1, MOS, RTP5, SYNPO2, SUMO1, IGSF8, ERBB2IP, CAPN1, ZNF446, RPL35, UBC, NOS3, ACTN1, ACTN4, FBXL22, COIL, SUMO3, ATXN2, KCNA5, LDB3, KCNN2, PSMA3, ITGB3BP, SNW1, MED14, NR1I2, KAT2B, NRIP1, ATXN7,
    Protein Size: 894

    Molekulargewicht

    104 kDa

    Gen-ID

    88

    NCBI Accession

    NM_001103, NP_001094

    UniProt

    P35609

    Pathways

    Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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