ACTN2 Antikörper (N-Term)
Kurzübersicht für ACTN2 Antikörper (N-Term) (ABIN2776829)
Target
Alle ACTN2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- N-Term
-
Sequenz
- NQIEPGVQYN YVYDEDEYMI QEEEWDRDLL LDPAWEKQQR KTFTAWCNSH
-
Homologie
- Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
-
Produktmerkmale
- This is a rabbit polyclonal antibody against ACTN2. It was validated on Western Blot using a cell lysate as a positive control.
-
Aufreinigung
- Affinity Purified
-
Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ACTN2
-
-
-
-
Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
-
Kommentare
-
Antigen size: 894 AA
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- Lot specific
-
Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
-
BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 5, pp. 1155-65, (2008) (PubMed).
: "
-
BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 5, pp. 1155-65, (2008) (PubMed).
-
- ACTN2 (Actinin, alpha 2 (ACTN2))
-
Andere Bezeichnung
- ACTN2
-
Hintergrund
-
The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-39 DC378038.1 17-55 40-2961 BC051770.1 1-2922 2962-3458 CB153006.1 65-561 3459-3637 AL359185.25 28531-28709 3638-4210 M86406.1 3609-4181 4211-4528 AL359185.25 29283-29600
Alias Symbols: CMD1AA
Protein Interaction Partner: ACTN2, FAM154A, BRMS1L, MICALL2, MYOZ2, PDLIM3, SP100, SNAI1, MOS, RTP5, SYNPO2, SUMO1, IGSF8, ERBB2IP, CAPN1, ZNF446, RPL35, UBC, NOS3, ACTN1, ACTN4, FBXL22, COIL, SUMO3, ATXN2, KCNA5, LDB3, KCNN2, PSMA3, ITGB3BP, SNW1, MED14, NR1I2, KAT2B, NRIP1, ATXN7,
Protein Size: 894 -
Molekulargewicht
- 104 kDa
-
Gen-ID
- 88
-
NCBI Accession
- NM_001103, NP_001094
-
UniProt
- P35609
-
Pathways
- Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
Target
-