MUC1 Antikörper (C-Term)

Produktnummer ABIN2776827

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MUC1 in IHC. Er zeigt eine Reaktivität gegenüber Human und Schwein.

Kurzübersicht für MUC1 Antikörper (C-Term) (ABIN2776827)

Target: MUC1 (Mucin 1 (MUC1))

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-MUC1 Antikörper

Bindungsspezifität: C-Term

Sequenz: GCAGHCLSHC LGCLSVPPKE LRAAGHLSSP GYLPSYERVP HLPHPWALCA

Homologie: Human: 100%, Pig: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MUC1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MUC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 158 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MUC1

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: MUC1

Hintergrund: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Alias Symbols: CD227, EMA, H23AG, KL-6, MAM6, PEM, PEMT, PUM, MUC-1, MUC-1/X, MUC1/ZD, MUC-1/SEC
Protein Interaction Partner: UBC, PPARG, IPO5, NUP62, EGFR, ABL1, SRC, JUN, TP53, TBP, IKBKG, TNFRSF1A, IKBKB, GRB2, ESR1, GALNT15, GALNT12, GALNT10, OSGEP, GSK3B, GALNT2, GALNT1, CTNND1, SIGLEC1, ERBB4, ERBB3, SOS1, PRKCD, ZAP70, APC, JUP, LYN, ERBB2, LCK, CTNNB1, GALNT4, BAX, CDKN1
Protein Size: 158

Molekulargewicht: 14 kDa

Gen-ID: 4582

NCBI Accession: NM_001044393, NP_001037858

UniProt: Q7Z538

Pathways: Negative Regulation of intrinsic apoptotic Signaling