Uromodulin Antikörper (C-Term)
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- Target Alle Uromodulin (UMOD) Antikörper anzeigen
- Uromodulin (UMOD)
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Hund, Rind (Kuh)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Uromodulin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL
- Homologie
- Cow: 91%, Dog: 86%, Human: 100%, Mouse: 85%
- Produktmerkmale
- This is a rabbit polyclonal antibody against UMOD. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human UMOD
- Top Product
- Discover our top product UMOD Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 640 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Uromodulin (UMOD)
- Andere Bezeichnung
- UMOD (UMOD Produkte)
- Synonyme
- ADMCKD2 antikoerper, FJHN antikoerper, HNFJ antikoerper, HNFJ1 antikoerper, MCKD2 antikoerper, THGP antikoerper, THP antikoerper, urehr4 antikoerper, uromodulin antikoerper, UMOD antikoerper, Umod antikoerper
- Hintergrund
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This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Alias Symbols: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Protein Interaction Partner: LTA, MMP8,
Protein Size: 640 - Molekulargewicht
- 67 kDa
- Gen-ID
- 7369
- NCBI Accession
- NM_001008389, NP_001008390
- UniProt
- P07911
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