Uromodulin Antikörper (C-Term)

Produktnummer ABIN2776813

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Uromodulin in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Hund und Rind (Kuh).

Kurzübersicht für Uromodulin Antikörper (C-Term) (ABIN2776813)

Target: Uromodulin (UMOD)

Reaktivität: Human, Maus, Hund, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Uromodulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Uromodulin Antikörper

Bindungsspezifität: C-Term

Sequenz: PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL

Homologie: Cow: 91%, Dog: 86%, Human: 100%, Mouse: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against UMOD. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human UMOD

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 640 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Uromodulin

Target: Uromodulin (UMOD)

Andere Bezeichnung: UMOD

Hintergrund: This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Alias Symbols: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Protein Interaction Partner: LTA, MMP8,
Protein Size: 640

Molekulargewicht: 67 kDa

Gen-ID: 7369

NCBI Accession: NM_001008389, NP_001008390

UniProt: P07911