DCP2 Antikörper (C-Term)

Produktnummer ABIN2776652

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DCP2 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Meerschweinchen, Hund, Pferd, Schwein und Rind (Kuh).

Kurzübersicht für DCP2 Antikörper (C-Term) (ABIN2776652)

Target: DCP2 (DCP2 Decapping Enzyme Homolog (DCP2))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Hund, Pferd, Schwein, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DCP2 Antikörper

Bindungsspezifität: C-Term

Sequenz: VEKLSRTKFR HSQQLFPDGS PGDQWVKHRQ PLQQKPYNNH SEMSDLLKGK

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against DCP2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DCP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 420 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DCP2

Target: DCP2 (DCP2 Decapping Enzyme Homolog (DCP2))

Andere Bezeichnung: DCP2

Hintergrund: DCP2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a poly(A) tail, but has no activity towards a cap structure lacking a RNA moiety.DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-539 AY135173.1 1-539 540-1992 AK090564.1 481-1933 1993-8947 AC008536.7 154323-161277
Alias Symbols: FLJ33245, NUDT20
Protein Interaction Partner: FAM96B, DCP1A, UBC, EDC4, DCP1B, SFXN2, ANGEL2, ARMCX5, DARS2, ELP3, QPCTL, GTPBP2, TRMT2A, FBXO3, INTS7, POLD3, GFPT2, AP1M1, SQSTM1, IKBKAP, TRRAP, TARS, ABCE1, PHKB, PGM3, PFKM, IDE, GLUD1, GGT7, GGCX, GFPT1, GARS, FANCD2, EIF5A, SLC25A10, CAPN2, NAGK,
Protein Size: 420

Molekulargewicht: 48 kDa

Gen-ID: 167227

NCBI Accession: NM_152624, NP_689837

UniProt: Q8IU60