TIA1 Antikörper (C-Term)

Produktnummer ABIN2776556

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TIA1 in WB und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Kaninchen, Meerschweinchen und Pferd.

Kurzübersicht für TIA1 Antikörper (C-Term) (ABIN2776556)

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-TIA1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: TIA1 Antibody - C-terminal region

Sequenz: QAWNQQGFNQ TQSSAPWMGP NYGVQPPQGQ NGSMLPNQPS GYRVAGYETQ

Homologie: Cow: 82%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TIA1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TIA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40981-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu TIA1

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Andere Bezeichnung: TIA1

Hintergrund:

Background Information: TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing.The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Gene Name: TIA1 cytotoxic granule-associated RNA binding protein

Alternative Symbols: WDM, ALS26, TIA-1

Protein Name: Nucleolysin TIA-1 isoform p40

Molekulargewicht: 42 kDa

Gen-ID: 7072

NCBI Accession: NP_071320

UniProt: P31483