HSBP1 Antikörper (N-Term)

Produktnummer ABIN2776380

Der Kaninchen Polyklonal Anti-HSBP1-Antikörper wurde für WB validiert. Er ist geeignet, HSBP1 in Proben von Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio) und Meerschweinchen zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für HSBP1 Antikörper (N-Term) (ABIN2776380)

Target: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HSBP1 Antikörper

Bindungsspezifität: N-Term

Sequenz: AETDPKTVQD LTSVVQTLLQ QMQDKFQTMS DQIIGRIDDM SSRIDDLEKN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HSBP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HSBP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 76 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HSBP1 Antikörper (ABIN2776380)

Tai, McFall, Huang, Demeler, Fox, Brubaker, Radhakrishnan, Morimoto: "Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 735-45, (2002) (PubMed).

Details zu HSBP1

Target: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Andere Bezeichnung: HSBP1

Hintergrund: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
Alias Symbols: DKFZp686D1664, DKFZp686O24200, NPC-A-13
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-7, LNX1, KIAA1217, CCHCR1, CCDC53, SDCBP, KIFC3, HSBP1, UBC, VCP, RRBP1, RB1CC1, HSF1, HSPA1A, HSPA4,
Protein Size: 76

Molekulargewicht: 8 kDa

Gen-ID: 3281

NCBI Accession: NM_001537, NP_001528

UniProt: O75506

Pathways: SARS-CoV-2 Protein Interaktom