KLF6 Antikörper (Middle Region)

Produktnummer ABIN2776377

Der Kaninchen Polyklonal anti-KLF6 Antikörper wird verwendet zum Nachweis von KLF6 in Proben von Human, Ratte, Maus, Hund, Pferd, Meerschweinchen, Kaninchen und Rind (Kuh). Er wurde validiert für WB.

Kurzübersicht für KLF6 Antikörper (Middle Region) (ABIN2776377)

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Reaktivität: Human, Ratte, Maus, Hund, Pferd, Meerschweinchen, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KLF6 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: KLF6 Antibody - middle region

Sequenz: SREPSQLWGC VPGELPSPGK VRSGTSGKPG DKGNGDASPD GRRRVHRCHF

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against KLF6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KLF6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104061

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu KLF6

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Andere Bezeichnung: KLF6

Hintergrund:

Background Information: KLF6 is a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. KLF6 may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: Kruppel-like factor 6

Alternative Symbols: GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEB

Protein Name: Krueppel-like factor 6

Molekulargewicht: 32kDa

Gen-ID: 1316

NCBI Accession: NP_001291

UniProt: Q99612