DMP1 Antikörper (Middle Region)
Kurzübersicht für DMP1 Antikörper (Middle Region) (ABIN2776044)
Target
Alle DMP1 (DMTF1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- Middle Region
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                                            Sequenz
- TFPDEIHHPK MTVEPSFNDA HVSKFSDQNS TELMNSVMVR TEEEISDTDL
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                                            Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 86%
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                                            Produktmerkmale
- This is a rabbit polyclonal antibody against DMTF1. It was validated on Western Blot using a cell lysate as a positive control.
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                                            Aufreinigung
- Affinity Purified
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                                            Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human DMTF1
 
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                                            Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
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                                            Kommentare
- 
                        Antigen size: 760 AA 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Liquid
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                                            Konzentration
- Lot specific
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                                            Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Handhabung
- Avoid repeated freeze-thaw cycles.
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                                            Lagerung
- -20 °C
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                                            Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
 
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    - DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
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                                            Andere Bezeichnung
- DMTF1
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                                            Hintergrund
- 
                        DMTF1 is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. DMTF1 is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of DMTF1 is regulated by binding of D-cyclins. The gene encoding DMTF1 is hemizygously deleted in approximately 40 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.
 Alias Symbols: DMP1, DMTF, FLJ41265, hDMP1
 Protein Interaction Partner: SRA1, TP53, ATF7IP, CCND1, CCND3, CCND2,
 Protein Size: 760
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                                            Molekulargewicht
- 84 kDa
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                                            Gen-ID
- 9988
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                                            NCBI Accession
- NM_021145, NP_066968
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                                            UniProt
- Q9Y222
 Target
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