THRA Antikörper (Middle Region)

Produktnummer ABIN2776019

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch THRA in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Schaf, Meerschweinchen und Zebrafisch (Danio rerio) und wurde in 1 Publikation erwähnt.

Kurzübersicht für THRA Antikörper (Middle Region) (ABIN2776019)

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Schaf, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-THRA Antikörper

Bindungsspezifität: Middle Region

Sequenz: DQIILLKGCC MEIMSLRAAV RYDPESDTLT LSGEMAVKRE QLKNGGLGVV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against THRA. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human THRA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 490 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-THRA Antikörper (ABIN2776019)

Kiss-Toth, Harlock, Lath, Quertermous, Wilkinson: "A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation." in: PLoS ONE, Vol. 8, Issue 9, pp. e76034, (2013) (PubMed).

Details zu THRA

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Andere Bezeichnung: THRA

Hintergrund: The THRA gene encodes a protein that is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone.
Alias Symbols: AR7, EAR7, ERB-T-1, ERBA, ERBA1, MGC000261, MGC43240, NR1A1, THRA1, THRA2, c-ERBA-1, CHNG6
Protein Interaction Partner: L3MBTL3, AMOTL2, RANBP9, NCOR1, PTGES3, THRA, RXRA, FOXJ1, CLIC1, C1D, NCOR2, BUB3, tat, GTF2B, ARID5A, SUMO1, SUMO3, MED1, NRIP1, MED21, CDK7, MED25, RGN, CUL1, SEPP1, TBL1XR1, HDAC3, SMC1A, XRCC5, TBL1X, PRKDC, LIG3, HSPA4, GPS2, XRCC6, PARP1, EMD, GRIP
Protein Size: 490

Molekulargewicht: 55 kDa

Gen-ID: 7067

NCBI Accession: NM_003250, NP_003241

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development