CREM Antikörper (N-Term)

Produktnummer ABIN2776016

Produktdetails anti-CREM Antikörper

Target: CREM (CAMP Responsive Element Modulator (CREM))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Schaf, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CREM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAAATGDMPT YQIRAPTAAL PQGVVMAASP GSLHSPQQLA EEATRKRELR

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CREM. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CREM

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 120 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CREM Antikörper (ABIN2776016)

Sunahori, Juang, Tsokos: "Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 3, pp. 1500-8, (2009) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Details zu CREM

Target: CREM (CAMP Responsive Element Modulator (CREM))

Andere Bezeichnung: CREM (CREM Produkte)

Synonyme: CREM antikoerper, ICER antikoerper, CREM-2 antikoerper, hCREM-2 antikoerper, ICERI antikoerper, Icer antikoerper, cAMP responsive element modulator antikoerper, CREM antikoerper, Crem antikoerper

Hintergrund: CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Alias Symbols: ICER, CREM-2, hCREM-2
Protein Interaction Partner: CREB1, PIAS3, CASP8AP2, UBE2I, UBC, SP100, ATXN1, EMP3, HHV8GK18_gp81, MAPK3, CREB3L4, HDAC1, CREB3L1, TAF4, CAMK2D, GSK3A, FHL5, GSK3B, KCNIP3, CAMK2G, PRKACA, CSNK1A1, CREBBP, TBP, PRKCA, SPI1, CREM, ATF1, CDC34, CDK1, CSNK2A2, CSNK2A1, CD34,
Protein Size: 120

Molekulargewicht: 13 kDa

Gen-ID: 1390

NCBI Accession: NM_182717, NP_874386

UniProt: O75519

Pathways: Retinoic Acid Receptor Signaling Pathway