KEAP1 Antikörper (N-Term)

Produktnummer ABIN2775978

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KEAP1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Schwein, Kaninchen, Rind (Kuh), Hund, Pferd und Zebrafisch (Danio rerio).

Kurzübersicht für KEAP1 Antikörper (N-Term) (ABIN2775978)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reaktivität: Human, Maus, Ratte, Schwein, Kaninchen, Rind (Kuh), Hund, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KEAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-KEAP1 Antikörper

Bindungsspezifität: N-Term

Sequenz: SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT KQAFGIMNEL

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against KEAP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KEAP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 624 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Andere Bezeichnung: KEAP1

Hintergrund: KEAP1 contains KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Alias Symbols: INrf2, KLHL19
Protein Interaction Partner: OXR1, ZSCAN32, LSM3, KLHL3, FBXW11, MAPKBP1, NUDT4, DPP3, RBX1, ATG5, SQSTM1, PTMA, PRKAG1, NFE2L2, MAD2L1, GYPA, ETF1, BCL2, CUL3, RECK, UBC, PGAM5, FAM117B, WDR83, CCNB1IP1, HSP90AA1, XPO1, MCMBP, KEAP1, SLK, MCM3, IKBKB, AMER1, GPRASP2, PRKCE, NFE2L1,
Protein Size: 624

Molekulargewicht: 70 kDa

Gen-ID: 9817

NCBI Accession: NM_203500, NP_987096

UniProt: Q14145

Pathways: Maintenance of Protein Location